intermediate of letrozole
4,4'-Dicyanobenzophenone
CAS: 32446-66-5
Molecular Formula: C15H8N2O
intermediate of letrozole - Names and Identifiers
| Name | 4,4'-Dicyanobenzophenone |
| Synonyms | AKOS BB-8277 Letrozole Impurity 5 4,4'-Dicyanobenzophenone 4,4'-DICYANOBENZOPHENONE Bis(4-cyanophenyl) Ketone intermediate of letrozole 4,4'-carbonyldibenzonitrile 4,4'-Carbonylbis-benzonitrile N-(2-AMINO-BENZOTHIAZOL-6-YL)-ACETAMIDE N-(2-AMINOBENZO[D]THIAZOL-6-YL) ACETAMIDE N-(2-AMINO-1,3-BENZOTHIAZOL-6-YL)ACETAMIDE |
| CAS | 32446-66-5 |
| EINECS | 1533716-785-6 |
| InChI | InChI=1/C15H8N2O/c16-9-11-1-5-13(6-2-11)15(18)14-7-3-12(10-17)4-8-14/h1-8H |
intermediate of letrozole - Physico-chemical Properties
| Molecular Formula | C15H8N2O |
| Molar Mass | 232.24 |
| Density | 1.26±0.1 g/cm3(Predicted) |
| Melting Point | 162 °C |
| Boling Point | 457.8±30.0 °C(Predicted) |
| Flash Point | 230.658°C |
| Solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Solid |
| Color | Light Brown to Brown |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.631 |
| Physical and Chemical Properties | Appearance light yellow powder |
intermediate of letrozole - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Hazard Class | IRRITANT |
intermediate of letrozole - Introduction
4,4 '-Dicyanobenzophenone(4,4'-Dicyanobenzophenone) is an organic compound with the molecular formula C15H8N2O and a molecular weight of 240.24g/mol. It is a yellow crystalline solid, soluble in organic solvents such as ethanol and dimethylformamide.
4,4 '-Dicyanobenzophenone is widely used in chemical synthesis. It can act as a photoinitiator to promote photochemical reactions by absorbing ultraviolet light and generating reactive species. In addition, it can also be used as an intermediate in the synthesis of organic dyes and fluorescent materials.
The method for preparing 4,4 '-Dicyanobenzophenone is to react Dicyanobenzophenone with cyanide. First, Dicyanobenzophenone and sulfoxide are reacted to form a sulfoxide salt; Then, under the catalysis of a base, the sulfoxide salt is reacted with a cyanide such as ferric chloride to obtain 4,4 '-Dicyanobenzophenone.
Since 4,4 '-Dicyanobenzophenone is a commonly used reagent in organic synthesis, it is necessary to pay attention to its safe use. It is an irritant substance and may cause irritation when in contact with the skin and eyes. In the use of the process, should avoid the inhalation of dust or gas, keep good ventilation. Also wear appropriate protective equipment such as gloves and goggles. If ingested or inhaled, seek medical attention promptly.
4,4 '-Dicyanobenzophenone is widely used in chemical synthesis. It can act as a photoinitiator to promote photochemical reactions by absorbing ultraviolet light and generating reactive species. In addition, it can also be used as an intermediate in the synthesis of organic dyes and fluorescent materials.
The method for preparing 4,4 '-Dicyanobenzophenone is to react Dicyanobenzophenone with cyanide. First, Dicyanobenzophenone and sulfoxide are reacted to form a sulfoxide salt; Then, under the catalysis of a base, the sulfoxide salt is reacted with a cyanide such as ferric chloride to obtain 4,4 '-Dicyanobenzophenone.
Since 4,4 '-Dicyanobenzophenone is a commonly used reagent in organic synthesis, it is necessary to pay attention to its safe use. It is an irritant substance and may cause irritation when in contact with the skin and eyes. In the use of the process, should avoid the inhalation of dust or gas, keep good ventilation. Also wear appropriate protective equipment such as gloves and goggles. If ingested or inhaled, seek medical attention promptly.
Last Update：2024-04-10 22:29:15
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